MovDisordV3, Main, Exploration, bibRecord, 002E21

Height as a potential indicator of early life events predicting Parkinson's disease: A case‐control study

Identifieur interne : 002E21 ( Main/Exploration ); précédent : 002E20; suivant : 002E22

Height as a potential indicator of early life events predicting Parkinson's disease: A case‐control study

Auteurs : Paolo Ragonese [Italie] ; Marco D'Amelio [Italie] ; Graziella Callari [Italie] ; Fabio Aiello [Italie] ; Letterio Morgante [Italie] ; Giovanni Savettieri [Italie]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-11-15.

RBID : ISTEX:54E294A8ADE7D1950E1FE886E2C4AB4E8069E9A7

Descripteurs français

Pascal (Inist)
- Epidémiologie, Etude cas témoin, Evénement existentiel, Facteur risque, Maladie de Parkinson, Pathologie du système nerveux.

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Body Height, Case control study, Case-Control Studies, Epidemiology, Female, Humans, Life events, Logistic Models, Male, Middle Aged, Nervous system diseases, Odds Ratio, Parkinson Disease (epidemiology), Parkinson disease, Parkinson's disease, Predictive Value of Tests, Risk Factors, Risk factor, anthropometric measures, epidemiology, height, risk factors.
MESH :
- epidemiology : Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Body Height, Case-Control Studies, Female, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Predictive Value of Tests, Risk Factors.

Abstract

Aim of this study was to investigate the relationship between height in young adult age and Parkinson's disease (PD) risk. We included 266 persons affected by idiopathic PD. Patients were matched by age and sex to 266 controls by a random selection from the municipality of residence. We collected information about height preceding PD from official documents where these characteristics referred to young adult age (nearly 30 years). We compared height in cases and controls by calculating differences in mean distribution and by χ2 analyses. Crude and adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated by logistic regression models. Mean height was significantly lower in persons affected by PD compared to controls (P = 0.03). Difference was significant only in men (P = 0.001). Logistic regression models showed an inverse association between height and PD (OR 0.35; CI 0.16, 0.79; P < 0.01 comparing individuals in the highest percentiles of height with those in the lowest). Our results indicate an association between height and PD in men. Considering that dopamine sensitivity in the hypothalamic‐pituitary axis is related to adult height, our findings suggest a relationship between PD and factors modulating somatic growth early in life. © 2007 Movement Disorder Society

Url:

https://api.istex.fr/document/54E294A8ADE7D1950E1FE886E2C4AB4E8069E9A7/fulltext/pdf

DOI: 10.1002/mds.21728

Affiliations:

Italie

Le document en format XML

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<front><div type="abstract" xml:lang="en">Aim of this study was to investigate the relationship between height in young adult age and Parkinson's disease (PD) risk. We included 266 persons affected by idiopathic PD. Patients were matched by age and sex to 266 controls by a random selection from the municipality of residence. We collected information about height preceding PD from official documents where these characteristics referred to young adult age (nearly 30 years). We compared height in cases and controls by calculating differences in mean distribution and by χ2 analyses. Crude and adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated by logistic regression models. Mean height was significantly lower in persons affected by PD compared to controls (P = 0.03). Difference was significant only in men (P = 0.001). Logistic regression models showed an inverse association between height and PD (OR 0.35; CI 0.16, 0.79; P < 0.01 comparing individuals in the highest percentiles of height with those in the lowest). Our results indicate an association between height and PD in men. Considering that dopamine sensitivity in the hypothalamic‐pituitary axis is related to adult height, our findings suggest a relationship between PD and factors modulating somatic growth early in life. © 2007 Movement Disorder Society</div>
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Movement Disorders (revue)

Height as a potential indicator of early life events predicting Parkinson's disease: A case‐control study

Height as a potential indicator of early life events predicting Parkinson's disease: A case‐control study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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